CJC-1295 + Ipamorelin: evidence, schedules, and safety
Medically reviewed by the Rite Aid Health Team · Last updated August 14, 2026
CJC-1295 and ipamorelin are paired to stimulate a growth-hormone pulse through two different receptors. The CJC-related component supplies a growth-hormone-releasing hormone signal. Ipamorelin supplies a ghrelin-receptor signal. The choice between DAC and no-DAC formulations changes the schedule more than the stack name suggests.
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How the two signals differ
CJC-1295 with DAC is a long-acting growth-hormone-releasing hormone analog. Ipamorelin is a selective growth-hormone secretagogue that acts at the ghrelin receptor. Human pharmacology research measured growth-hormone-axis effects from CJC-1295, while a later ipamorelin trial studied intravenous treatment after bowel surgery rather than a wellness protocol. Sources: CJC-1295 human pharmacokinetic study, Ipamorelin selectivity study, Ipamorelin postoperative ileus trial
The job assigned to each peptide
- CJC-related peptide. Provides the releasing-hormone signal that helps set up a growth-hormone pulse.
- Ipamorelin. Adds a second receptor signal and is often chosen because preclinical selectivity research found less cortisol and prolactin release than with older GHRPs.
- The pair. Used around sleep, recovery, or body-composition goals because users want both signals in the same pulse.
CJC-1295 with DAC versus no DAC
CJC-1295 with DAC binds to albumin and lasts for days. Products called “CJC-1295 no DAC” usually contain short-acting Mod GRF 1-29, a different molecule. A label that says only CJC-1295 does not provide enough information to choose a dosage schedule or calculate a blend.
How one clinic distinguishes DAC and no DAC
Beverly Hills Rejuvenation Center’s clinician-reviewed guide describes a no-DAC blend with 100 mcg of each component at bedtime on five days per week, with reported cycles of eight to twelve weeks. Its long-acting DAC pattern instead uses 1 to 2 mg of CJC-1295 once or twice weekly. The figures show that clinic’s practice and are not Rite Aid dosing instructions. Sources: BHRC reported-practice guide
How blend ratios change the calculation
A 1:1 blend delivers equal micrograms of both ingredients at every syringe mark. Other blends use unequal vial amounts, so the same draw produces different doses. Confirm whether the vial contains CJC-1295 with DAC or Mod GRF 1-29, then calculate each ingredient from the stated vial contents.
Side effects and monitoring questions
- IGF-1 helps show how strongly the growth-hormone axis is responding.
- Fasting glucose or A1c can identify worsening glucose control.
- Swelling, tingling or numbness, headaches, joint pain, and injection-site reactions deserve review.
- Cancer history, pituitary disease, pregnancy, and untreated sleep apnea can change the risk discussion.
What remains uncertain about the pair
Controlled human trials have not established a clinical benefit, long-term safety profile, ideal ratio, or monitoring protocol for CJC-1295 plus ipamorelin. Hormone release explains the pairing, but it does not settle those outcome questions.
Calculate units only after identifying the vial
The peptide calculator can convert the amount of each ingredient, water volume, and clinician-supplied target into syringe units. The result is reliable only when the molecular name and blend ratio are reliable.
Related
Sources
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Useful before or after you start
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For general education only — not medical advice or a treatment recommendation. Peptides are not a substitute for care from a licensed provider. Talk to a qualified healthcare professional before you start, stop, or change any peptide, medication, or supplement.
FAQ
The marketplace often uses those names as if they were the same. Mod GRF 1-29 is the short-acting molecule usually sold under the no-DAC label.
Users try to align a short-acting injection with the body’s overnight growth-hormone rhythm. Bedtime timing is a reported convention, not a proven requirement.
No. The DAC molecule lasts much longer, while Mod GRF 1-29 is short acting. Confirm the formulation before comparing schedules.