Peptide half-lives and dosing cadence
Reviewed by the Rite Aid Health Team · Last updated July 2, 2026
A peptide's half-life is roughly how long it stays active in the body, and it is the main thing that sets how often you dose.
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At a glance
| Peptide | Approx. half-life | Typical cadence |
|---|---|---|
| Sermorelin | ~10–20 min | Nightly |
| Tesamorelin | ~30 min | Once daily |
| Ipamorelin | ~2 hours | 1–3× daily |
| CJC-1295 (no DAC) | ~30 min | Daily, before bed |
| CJC-1295 (with DAC) | ~6–8 days | Weekly |
| BPC-157 | Hours | 1–2× daily |
| TB-500 | Days | Weekly |
| MK-677 (oral) | ~24 hours | Once daily |
Why it drives cadence
A short half-life means the compound clears quickly, so it is dosed more often (sometimes daily or twice daily) to keep levels up. A long half-life — like CJC-1295 with DAC — lets you dose weekly. Figures here are approximate and reported, not a prescription.
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For general education only — not medical advice or a treatment recommendation. Peptides are not a substitute for care from a licensed provider. Talk to a qualified healthcare professional before you start, stop, or change any peptide, medication, or supplement.
FAQ
The DAC (Drug Affinity Complex) binds it to albumin in the blood, stretching its half-life to several days, so a weekly injection keeps growth-hormone signalling elevated.
No — it just changes how often you dose. Effectiveness depends on the compound and your protocol, not the half-life alone.