Synthroid
PrescriptionWhat is Synthroid?
Synthroid is a prescription medication that contains levothyroxine sodium. This is a synthetic version of the thyroid hormone T4, which your thyroid gland normally makes. When your thyroid does not produce enough hormone, Synthroid replaces what is missing.
Millions of people take Synthroid every day to manage hypothyroidism. This condition happens when the thyroid gland is underactive. The medication comes in tablet form and is taken once daily. Different strengths are available to match your specific hormone needs.
Synthroid works best when taken on an empty stomach, usually 30 to 60 minutes before breakfast. Consistency matters with this medication. Taking it the same way every day helps maintain steady hormone levels in your body.
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Common uses
- Treating hypothyroidism, or underactive thyroid
- Managing thyroid hormone levels after thyroid surgery
- Suppressing thyroid stimulating hormone in thyroid cancer patients
- Treating goiter, an enlarged thyroid gland
- Managing congenital hypothyroidism in infants and children
How it works
Synthroid replaces the thyroid hormone T4 that your body needs but cannot make enough of on its own. After you take it, your body converts some of this T4 into T3, another important thyroid hormone. These hormones control your metabolism, which affects how your body uses energy.
Thyroid hormones influence almost every cell in your body. They help regulate your heart rate, body temperature, energy levels, and weight. When levels are too low, you may feel tired, cold, or gain weight. Synthroid brings hormone levels back to normal, which helps these symptoms improve over time.
Taking Synthroid? Monitor your levels.
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Dosage information
Typical starting doses range from 25 to 50 micrograms daily for adults. Some patients may need 100 to 125 micrograms or more. Your doctor will determine your exact dose based on your age, weight, and thyroid hormone levels. Doses are adjusted based on blood test results, usually checked every 6 to 8 weeks until levels stabilize. Once stable, testing happens every 6 to 12 months. Always take Synthroid exactly as prescribed by your doctor.
Side effects
- Hair loss during the first few months of treatment
- Headache
- Increased appetite
- Weight changes
- Heat sensitivity or increased sweating
- Trouble sleeping
- Nervousness or irritability
Serious side effects require immediate medical attention. These include chest pain, rapid or irregular heartbeat, shortness of breath, or signs of allergic reaction. If your dose is too high, you may experience symptoms of hyperthyroidism such as tremors, anxiety, or severe sweating. Contact your doctor if side effects persist or worsen.
Drug interactions
- Calcium supplements and antacids containing calcium or aluminum
- Iron supplements and multivitamins containing iron
- Proton pump inhibitors such as omeprazole or lansoprazole
- Cholesterol medications like cholestyramine or colestipol
- Diabetes medications, which may need dose adjustments
- Blood thinners such as warfarin
- Estrogen-containing birth control pills or hormone therapy
- Soy products, which can affect absorption
- Coffee, which may reduce absorption if taken together
Blood test monitoring
Regular blood tests are essential while taking Synthroid to ensure your dose is correct. Your doctor will check your thyroid stimulating hormone, also called TSH, which shows if your thyroid medication dose is right. Free T4 levels may also be tested to see how much active thyroid hormone is in your blood. Some doctors check free T3 as well. Testing typically happens 6 to 8 weeks after starting Synthroid or changing your dose. Once your levels are stable, you will need testing every 6 to 12 months. Rite Aid offers blood testing services that measure over 200 biomarkers, including TSH, free T4, and free T3, helping you track your thyroid health between doctor visits.
Related blood tests
Taking Synthroid? Monitor your levels.
- Track how your body responds
- Catch side effects early with blood work
- Share results with your doctor
Frequently asked questions
Yes, Rite Aid Pharmacy will fill Synthroid prescriptions when pharmacy services return soon. You can submit your prescription information now to be notified when services are available. Rite Aid pharmacists can answer questions about taking your thyroid medication properly.
Most people begin feeling better within 1 to 2 weeks of starting Synthroid. However, it takes 6 to 8 weeks for the medication to reach its full effect in your body. Your doctor will wait this long before adjusting your dose based on blood test results.
Take the missed dose as soon as you remember if it is the same day. If you remember the next day, skip the missed dose and take your regular dose. Never take two doses at once to make up for a missed dose.
Food can interfere with how well your body absorbs Synthroid. Taking it 30 to 60 minutes before breakfast ensures consistent absorption. Wait at least 4 hours after taking Synthroid before consuming calcium or iron supplements, which also affect absorption.
Most people with hypothyroidism need lifelong thyroid hormone replacement. Your thyroid condition is usually chronic, meaning it does not go away. Regular monitoring helps ensure your dose stays right as your needs may change over time.
You should not switch between brand name and generic thyroid medications without your doctor's guidance. Even small differences in absorption can affect your thyroid levels. If you do switch, your doctor will recheck your blood levels after 6 to 8 weeks.
Your doctor will primarily monitor TSH, which shows if your dose is correct. Free T4 and sometimes free T3 may also be checked. Rite Aid blood testing services include these thyroid biomarkers, giving you access to monitoring between regular doctor visits.
Yes, Synthroid is safe and important during pregnancy and breastfeeding. Your thyroid hormone needs actually increase during pregnancy. Your doctor will monitor your levels more frequently and may adjust your dose to keep both you and your baby healthy.
Signs of too much thyroid hormone include rapid heartbeat, tremors, anxiety, trouble sleeping, and unexplained weight loss. You may also feel overheated or notice increased sweating. Contact your doctor if you experience these symptoms so your dose can be adjusted.
Consistency matters more than the specific time. Most people take it first thing in the morning before eating. Some prefer taking it at bedtime, at least 4 hours after their last meal. Choose a time that works for you and stick with it every day.