Thyroid disorders have several different causes depending on the type. Autoimmune diseases are the most common cause of both hypothyroidism and hyperthyroidism. In Hashimoto's thyroiditis, your immune system attacks your thyroid and causes low hormone levels. In Graves' disease, your immune system causes your thyroid to make too much hormone. Other causes include thyroid nodules, thyroid surgery, radiation treatment to the neck, and certain medications like lithium.
Risk factors include being female, being over age 60, having a family history of thyroid disease, and having other autoimmune conditions. Pregnancy can trigger thyroid problems that may continue after delivery. Iodine deficiency or excess can also affect thyroid function. Certain medications, especially lithium used for bipolar disorder, can interfere with how your thyroid releases hormones and lead to thyroid dysfunction.