Respiratory failure develops when disease or injury damages your lungs or the muscles that control breathing. Chronic lung diseases like chronic obstructive pulmonary disease, severe asthma, and pulmonary fibrosis are common causes. Pneumonia, COVID-19, and other lung infections can trigger sudden respiratory failure. Injuries to the chest, spinal cord, or brain can disrupt the breathing signals your body needs. Neuromuscular diseases like muscular dystrophy and amyotrophic lateral sclerosis weaken the muscles used for breathing.
Risk factors include smoking or exposure to secondhand smoke, which damages lung tissue over time. Working with chemicals, dust, or fumes raises your risk. Sleep apnea that goes untreated can strain your respiratory system. Being overweight makes it harder for your lungs to expand fully. A history of severe allergies or repeated lung infections also increases your chances of developing respiratory problems.