Lung cancer

What is Lung cancer?

Lung cancer is a disease where abnormal cells grow out of control in one or both lungs. These cells form tumors that can interfere with your ability to breathe and get oxygen into your blood. It is one of the most common cancers worldwide and a leading cause of cancer deaths.

There are two main types of lung cancer. Non-small cell lung cancer makes up about 85% of cases and grows more slowly. Small cell lung cancer is less common but spreads more quickly. Both types can occur in different parts of the lung and may spread to other organs if not detected early.

Your lungs are responsible for bringing oxygen into your body and removing carbon dioxide. When cancer develops in lung tissue, it damages this vital exchange. Early detection improves treatment outcomes significantly. Understanding your risk factors and getting appropriate screening can help catch lung cancer at a more treatable stage.

Symptoms

  • A cough that does not go away or gets worse over time
  • Chest pain that worsens with deep breathing, coughing, or laughing
  • Coughing up blood or rust-colored spit
  • Shortness of breath or wheezing
  • Hoarseness or changes in your voice
  • Frequent lung infections like bronchitis or pneumonia
  • Feeling tired or weak without explanation
  • Loss of appetite or unexplained weight loss
  • Bone pain, especially in the back or hips
  • Headaches, dizziness, or balance problems if cancer has spread

Many people with early-stage lung cancer have no symptoms at all. This is why screening is so important for people at high risk. Symptoms often appear only after the cancer has grown or spread to other parts of the body.

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Causes and risk factors

Smoking is the leading cause of lung cancer, responsible for about 80 to 90% of cases. Tobacco smoke contains more than 70 cancer-causing chemicals. The longer you smoke and the more cigarettes you smoke each day, the higher your risk. Secondhand smoke also increases risk, even if you never smoked yourself.

Other risk factors include exposure to radon gas, asbestos, and certain metals like chromium. Occupational exposure to chromium(VI) is particularly concerning for workers in welding, chrome plating, and manufacturing industries. Air pollution, family history of lung cancer, and previous radiation therapy to the chest also raise your risk. Some people develop lung cancer without any known risk factors, though this is less common.

How it's diagnosed

Lung cancer is typically diagnosed through imaging tests like chest X-rays or CT scans. If a suspicious area is found, doctors perform a biopsy to examine cells under a microscope. Low-dose CT screening is recommended for people aged 50 to 80 who have a heavy smoking history and currently smoke or quit within the past 15 years.

Blood tests can sometimes help identify exposure to cancer-causing substances like chromium. While blood work alone cannot diagnose lung cancer, it may reveal risk factors or detect changes in your body that warrant further investigation. Talk to a doctor if you have symptoms or significant risk factors. They can recommend the appropriate screening tests and imaging studies for your situation.

Treatment options

  • Surgery to remove the tumor or part of the lung affected by cancer
  • Radiation therapy to kill cancer cells using high-energy beams
  • Chemotherapy medications that destroy cancer cells throughout the body
  • Targeted therapy drugs that attack specific mutations in cancer cells
  • Immunotherapy to help your immune system recognize and fight cancer
  • Quitting smoking immediately to improve treatment outcomes and survival
  • Pulmonary rehabilitation to improve breathing and physical function
  • Nutritional support to maintain strength during treatment
  • Pain management and palliative care to improve quality of life
  • Clinical trials offering access to new treatment approaches

Frequently asked questions

The earliest signs often include a persistent cough that does not go away after 2 to 3 weeks. You might notice chest pain, shortness of breath, or coughing up blood. Many people also experience unexplained fatigue or weight loss. However, early-stage lung cancer often has no symptoms, which is why screening is important for high-risk individuals.

Screening is recommended for adults aged 50 to 80 who have smoked at least 20 pack-years. A pack-year means smoking one pack per day for one year. You should currently smoke or have quit within the past 15 years. Talk to your doctor about whether screening is right for you based on your personal history.

Blood tests cannot directly diagnose lung cancer, but they can reveal important information. Tests measuring chromium levels may indicate occupational exposure that increases cancer risk. Blood work can also show general health markers and organ function. Imaging tests like CT scans remain the primary tool for detecting lung tumors.

No, though smoking causes 80 to 90% of lung cancer cases. Non-smokers can develop lung cancer from secondhand smoke, radon exposure, or occupational hazards. Air pollution and family history also play a role. About 10 to 20% of people diagnosed with lung cancer have never smoked.

Chromium is a metal used in many industrial processes like welding and chrome plating. The hexavalent form, chromium(VI), is a known carcinogen when inhaled. Workers in certain industries face higher exposure and increased lung cancer risk. Blood tests can measure chromium levels to assess exposure in at-risk individuals.

Early-stage lung cancer has much better survival rates than advanced disease. When caught at stage 1, the five-year survival rate can be 60% or higher. Surgery to remove the tumor is often successful at this stage. This is why screening for high-risk individuals is so important.

Quitting smoking is the single most important step you can take. Avoid secondhand smoke whenever possible. Test your home for radon and remediate if levels are high. If you work with chemicals or metals, follow all safety protocols and use protective equipment.

Lung cancer can have a genetic component, though environment plays a larger role. Having a parent or sibling with lung cancer increases your risk. Inherited genetic variations may make some people more susceptible. However, smoking and other exposures remain the primary drivers of lung cancer development.

Non-small cell lung cancer accounts for about 85% of cases and grows more slowly. It includes subtypes like adenocarcinoma and squamous cell carcinoma. Small cell lung cancer is less common but spreads more quickly to other parts of the body. The type affects treatment decisions and prognosis.

See a doctor if you have a cough lasting more than 3 weeks, especially with blood. Seek care for persistent chest pain, unexplained weight loss, or worsening shortness of breath. If you have a heavy smoking history or occupational exposures, discuss screening even without symptoms. Early evaluation leads to better outcomes.