Liver Disease/Cirrhosis
What is Liver Disease/Cirrhosis?
Liver disease refers to any condition that damages your liver and affects how it works. Your liver performs over 500 jobs in your body, including filtering toxins from your blood, making proteins, storing energy, and helping you digest food. When the liver is damaged over time, healthy tissue gets replaced by scar tissue in a process called fibrosis.
Cirrhosis is the most severe stage of liver scarring. In cirrhosis, so much scar tissue has built up that the liver cannot function properly anymore. This scarring is permanent and cannot be reversed. However, catching liver damage early gives you the chance to slow or stop the progression before it becomes cirrhosis.
Liver disease progresses through stages, from simple inflammation to fibrosis to cirrhosis. Many people have no symptoms in the early stages. This makes blood testing an important tool for detecting liver problems before permanent damage occurs. The earlier you catch liver dysfunction, the more you can do to protect this vital organ.
Symptoms
- Fatigue and weakness that interferes with daily activities
- Yellowing of the skin and eyes, called jaundice
- Itchy skin that persists without other cause
- Swelling in the legs, ankles, or abdomen
- Easy bruising or bleeding
- Loss of appetite and unintended weight loss
- Nausea or vomiting
- Dark-colored urine
- Pale or clay-colored stools
- Confusion or difficulty thinking clearly
- Spider-like blood vessels on the skin
Many people with early liver disease have no symptoms at all. The liver can lose significant function before you notice any problems. By the time symptoms appear, the disease may already be advanced. This is why proactive testing is so important for detecting liver issues early.
Concerned about Liver Disease/Cirrhosis? Check your levels.
Screen for 1,200+ health conditions
Causes and risk factors
Liver disease has many causes. Chronic alcohol use is one of the most common, as alcohol directly damages liver cells over time. Viral infections like hepatitis B and hepatitis C can cause ongoing inflammation that leads to scarring. Nonalcoholic fatty liver disease happens when fat builds up in the liver, often linked to obesity, diabetes, and metabolic syndrome. Autoimmune conditions can cause your immune system to attack your liver. Certain medications, toxins, and genetic disorders can also damage liver tissue.
Risk factors include drinking more than moderate amounts of alcohol, having obesity or diabetes, sharing needles, getting tattoos with unsterilized equipment, and having a family history of liver disease. High triglycerides, insulin resistance, and chronic inflammation throughout the body also increase your risk. Many of these risk factors are within your control through lifestyle changes. Addressing them early can prevent or slow liver damage before it becomes irreversible.
How it's diagnosed
Liver disease is diagnosed through a combination of medical history, physical exam, blood tests, and imaging. Blood tests check liver enzymes, protein levels, and other markers that reflect liver function. Fibrinogen is a protein made exclusively by liver cells, so low levels indicate that your liver has lost its ability to make proteins properly. This happens in advanced liver disease and cirrhosis. Other blood tests measure bilirubin, albumin, and clotting factors to assess how well your liver is working.
Rite Aid offers testing for fibrinogen as an add-on to our flagship panel. This biomarker helps evaluate liver synthetic function and can indicate advanced liver disease. Testing is available at over 2,000 Quest Diagnostics locations nationwide. Your doctor may also order imaging tests like ultrasound, CT scans, or MRI to look at liver structure. In some cases, a liver biopsy is needed to determine the extent of scarring.
Treatment options
- Stop drinking alcohol completely if alcohol is contributing to liver damage
- Lose weight gradually through balanced nutrition and regular physical activity if you have fatty liver disease
- Manage diabetes and keep blood sugar levels in a healthy range
- Eat a nutrient-dense diet with plenty of vegetables, lean protein, and healthy fats
- Avoid medications and supplements that can harm the liver, including high-dose acetaminophen
- Get vaccinated for hepatitis A and B to prevent additional liver damage
- Treat underlying conditions like hepatitis C with antiviral medications
- Take medications as prescribed to manage complications like fluid retention, infections, or brain fog
- Work with a liver specialist, called a hepatologist, for advanced disease
- In severe cirrhosis, liver transplant may be the only treatment option
Need testing for Liver Disease/Cirrhosis? Add it to your panel.
- Simple blood draw at your nearest lab
- Results in days, not weeks
- Share results with your doctor
Frequently asked questions
Liver disease is a general term for any condition that damages the liver. Cirrhosis is the most advanced stage of liver disease, where severe scarring prevents the liver from working properly. Not all liver disease progresses to cirrhosis if caught and treated early.
Early liver damage and inflammation can often be reversed with lifestyle changes and treatment of the underlying cause. However, once cirrhosis develops, the scarring is permanent. Stopping the damage at that point prevents further harm but cannot undo existing scar tissue.
Fibrinogen is a clotting protein made only by liver cells. When your liver is severely damaged, it cannot make fibrinogen properly, so blood levels drop. Low fibrinogen indicates advanced liver disease and reduced synthetic function, helping doctors assess how well your liver is working.
Early liver disease often has no symptoms. As damage progresses, you may notice fatigue, mild abdominal discomfort, or unexplained weight changes. Many people only discover liver problems through routine blood work, which is why proactive testing is so important.
Progression varies widely depending on the cause and individual factors. Some people develop cirrhosis within a few years, while others may take decades. Heavy alcohol use, untreated hepatitis, and severe fatty liver disease tend to progress faster than other causes.
Yes, many forms of liver disease are preventable even with a family history. Maintain a healthy weight, limit alcohol, avoid hepatitis exposure, and manage metabolic conditions like diabetes. Regular blood testing can catch early changes before serious damage occurs.
Limit or eliminate alcohol, maintain a healthy body weight, exercise regularly, and eat a balanced diet low in processed foods and added sugars. Avoid unnecessary medications and supplements, and get vaccinated for hepatitis. These steps protect your liver and support its natural repair processes.
Fatty liver disease can be serious if left untreated. Simple fat accumulation may not cause immediate problems, but it can progress to inflammation, fibrosis, and eventually cirrhosis. Addressing it early through weight loss, diet, and exercise can prevent progression and even reverse the fat buildup.
Testing frequency depends on your risk factors. People with diabetes, obesity, heavy alcohol use, or hepatitis should be tested at least yearly. If you have multiple risk factors or known liver disease, your doctor may recommend testing every 6 months to monitor progression.
See a doctor if you notice jaundice, persistent abdominal pain or swelling, unexplained weight loss, or easy bruising. If you have risk factors like heavy alcohol use or diabetes, get baseline testing even without symptoms. Early detection allows for intervention before permanent damage occurs.