Heart disease develops when plaque made of cholesterol, fat, and other substances builds up inside your arteries. This process is called atherosclerosis. Inflammation in your blood vessels speeds up plaque formation and increases risk. High cholesterol, especially high LDL and low HDL, contributes to blockages. High blood pressure damages artery walls over time. Smoking harms blood vessels and reduces oxygen in your blood. Diabetes raises your risk because high blood sugar damages arteries.
Other risk factors include being overweight, eating a diet high in processed foods and saturated fats, lack of physical activity, chronic stress, and excessive alcohol consumption. Family history plays a role too. Age increases risk, especially after 45 for men and 55 for women. Some nutrients like folate affect homocysteine levels, an amino acid linked to heart disease risk when elevated. Elevated GGT levels may also indicate increased risk, though researchers are still studying this connection.