Cancer develops when genetic changes allow cells to ignore normal growth signals. These changes can happen because of inherited genes, environmental exposures, lifestyle choices, or random cell mutations. Tobacco use causes about 30 percent of all cancer deaths in the United States. Smoking damages DNA and increases risk for lung, throat, mouth, pancreas, bladder, kidney, and other cancers. Exposure to toxic metals like cadmium and arsenic from cigarette smoke, contaminated water, or industrial work also raises cancer risk over time.
Diet and lifestyle play major roles in cancer development. Eating processed meats, drinking alcohol, having obesity, and living a sedentary lifestyle all increase risk. Chronic inflammation in the body creates an environment where cancer cells can thrive. Sun exposure without protection damages skin cells and leads to melanoma and other skin cancers. Some viruses and bacteria, including HPV and H. pylori, can trigger cancers. Family history matters too. Inherited gene mutations account for 5 to 10 percent of all cancers.