Adrenal Adenoma

What is Adrenal Adenoma?

An adrenal adenoma is a benign tumor that grows on one of your adrenal glands. Your adrenal glands sit on top of your kidneys and produce hormones that control blood pressure, metabolism, and stress response. Most adrenal adenomas are noncancerous and grow slowly over time.

Many adrenal adenomas are found by accident during imaging tests for other health issues. Some adenomas produce excess hormones, while others remain inactive and cause no symptoms. When an adenoma produces too much cortisol, it can lead to a condition called Cushing syndrome. This happens because the tumor makes cortisol on its own, without responding to your body's normal feedback signals.

Adrenal adenomas affect about 3 to 7 percent of adults. The condition becomes more common with age. Most people with these tumors never know they have them because they cause no problems. However, hormone-secreting adenomas require monitoring and treatment to prevent complications.

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Symptoms

Many people with adrenal adenomas have no symptoms, especially when the tumor does not produce excess hormones. When symptoms do occur, they typically relate to hormone imbalances caused by the tumor.

Weight gain, especially around the abdomen and face
High blood sugar or new-onset diabetes
High blood pressure that is hard to control
Muscle weakness and fatigue
Easy bruising and slow wound healing
Purple or pink stretch marks on skin
Thinning bones that break easily
Mood changes, anxiety, or depression
Increased thirst and urination
Changes in menstrual periods or decreased sex drive

Some people with hormone-secreting adenomas have subtle symptoms that develop gradually over months or years. This makes the condition easy to miss in early stages.

Causes and risk factors

The exact cause of adrenal adenomas remains unclear in most cases. These tumors develop when cells in the adrenal gland grow abnormally and form a mass. Most adenomas occur sporadically without any known trigger. Age is a major risk factor, as these tumors become more common after age 50. Some genetic conditions increase risk, including multiple endocrine neoplasia and familial adenomatous polyposis.

When an adenoma produces excess cortisol, it operates independently of your body's control systems. Normally, your pituitary gland regulates cortisol production through a feedback loop. Hormone-secreting adenomas ignore these signals and make cortisol continuously. This leads to elevated cortisol levels throughout the day and night, disrupting the normal daily rhythm of cortisol release. Obesity, high blood pressure, and metabolic syndrome may increase the likelihood of developing adrenal tumors, though the connection is not fully understood.

How it's diagnosed

Doctors typically discover adrenal adenomas through imaging tests like CT scans or MRIs done for other reasons. Once a tumor is found, blood tests help determine if it produces excess hormones. Cortisol testing is essential for identifying hormone-secreting adenomas. A simple blood test measuring total cortisol can reveal abnormal hormone levels. Doctors may also order additional tests to check cortisol patterns throughout the day, since healthy adrenal glands produce more cortisol in the morning and less at night.

Rite Aid offers cortisol testing as part of our flagship health panel. This makes it easy to check your hormone levels at over 2,000 Quest Diagnostics locations nationwide. Your results help identify whether an adrenal adenoma is affecting your cortisol production. If testing shows elevated cortisol or loss of normal daily variation, your doctor may recommend imaging studies to look for an adrenal tumor. Early detection through routine blood testing helps catch hormone imbalances before they cause serious complications.

Treatment options

Treatment for adrenal adenomas depends on whether the tumor produces hormones and how large it grows. Your doctor will help create a plan based on your specific situation.

Active monitoring with regular blood tests and imaging for small, non-functioning adenomas
Surgical removal for hormone-secreting tumors or large adenomas over 4 centimeters
Medications to block cortisol production or effects when surgery is not an option
Blood pressure medications to manage hypertension caused by excess hormones
Diabetes medications if high cortisol levels affect blood sugar control
Lifestyle changes including a balanced diet low in added sugars and processed foods
Regular physical activity to maintain healthy weight and bone strength
Stress management techniques to support overall hormone balance
Bone density monitoring and calcium supplements to prevent osteoporosis
Regular follow-up appointments to track tumor size and hormone levels

Frequently asked questions

An adrenal adenoma is a benign tumor that does not spread to other parts of the body. Adrenal cancer, called adrenocortical carcinoma, is rare and grows aggressively. Adenomas are far more common and usually cause no serious health problems. Imaging tests and biopsy can help doctors tell the difference between benign and cancerous tumors.

Adrenal adenomas typically do not disappear without treatment. These tumors usually remain stable in size or grow very slowly over many years. Non-functioning adenomas that cause no symptoms may never require treatment. However, hormone-secreting adenomas need medical intervention to prevent complications from excess cortisol or other hormones.

Testing frequency depends on whether your adenoma produces hormones. People with non-functioning adenomas may need annual cortisol checks to ensure the tumor remains inactive. Those with hormone-secreting tumors require more frequent testing, often every 3 to 6 months. Your doctor will create a monitoring schedule based on your tumor size, hormone levels, and symptoms.

Not everyone with an adrenal adenoma needs surgery. Doctors typically recommend removal for tumors that produce excess hormones or grow larger than 4 centimeters. Small, non-functioning adenomas can be safely watched with regular imaging and blood tests. Surgery is also considered if the tumor grows rapidly or shows concerning features on imaging studies.

After removing a cortisol-producing adenoma, hormone levels usually drop significantly. Some people need temporary cortisol replacement medication because the remaining adrenal tissue may not work properly at first. Normal adrenal function typically returns within weeks to months after surgery. Regular blood tests help doctors monitor recovery and adjust medications as needed.

Lifestyle changes cannot shrink an adrenal adenoma, but they help manage symptoms and complications. Eating a nutrient-dense diet supports overall hormone health and helps control blood sugar. Regular exercise maintains bone strength and healthy weight. Stress management techniques may help balance your stress response system, though they will not affect tumor growth or hormone production.

Most adrenal adenomas occur sporadically and are not inherited. However, certain rare genetic syndromes increase the risk of developing these tumors. People with multiple endocrine neoplasia or familial adenomatous polyposis have higher rates of adrenal adenomas. If you have a family history of endocrine tumors, talk to your doctor about genetic testing and screening.

Risks depend on whether the adenoma produces hormones. Non-functioning adenomas rarely cause problems and may never need treatment. Untreated cortisol-secreting adenomas can lead to serious complications including diabetes, severe osteoporosis, heart disease, and infections. High cortisol levels over time damage multiple body systems and significantly increase health risks.

Blood tests cannot directly detect adrenal tumors, but they reveal hormone imbalances caused by functioning adenomas. Cortisol testing is highly accurate for identifying excess hormone production. Elevated total cortisol levels, especially when the normal daily pattern is lost, strongly suggest a hormone-secreting tumor. Imaging tests are then needed to confirm the presence and location of the adenoma.

Yes, some people develop multiple adrenal adenomas on one or both adrenal glands. This is less common than having a single tumor. Multiple adenomas may be discovered during imaging studies for other health concerns. Each tumor should be evaluated separately to determine if it produces hormones and whether treatment is needed.